Lipoprotein

Lipoprotein

VLDL:

Synthesized inLiver.
Mostly composed of TG.

Lipid 90-93%

Function:
Transport TG from liver to peripheral tissue.

Metabolism :
Extrahepatic tissue by lipoprotein lipase

Metabolic end product:
FFA
Glycerol
IDL/VLDL remnent

Fate:
Taken by liver
converted to LDL

LDL:

Composed of 79% lipid
Protein 21%

Contains cholesterol and cholesterol ester.

Derived from VLDL in the plasma

Chief pathogenic factor for atherosclerosis.

Functions:
Provides cholesterol to peripheral tissues.

Metabolism:
30% extrahepatic tissue
70% inside liver.

HDL:

Lipid 33%
Protein 67%

Synthesized inside the liver.

Function:
Transport Cholesterol from peripheral tissue to liver.

Usually biconcave shape. When it picks up cholesterol it become round.

Transfer cholesterol to VLDL,LDL in exchange of TAG/TG
carry CE(ester) to liver
Remove free cholesterol from extrahepatic tissue by LCAT(lecithin cholesterol actyl transferase)